Novel Therapies for Intracerebral Hemorrhage

JHN Journal

Rincon, MD, MSc, FACP, FCCP, FCCM, Fred¹ 

[1] Department of Neurology, Thomas Jefferson UniversityDepartment of Neurology, Thomas Jefferson UniversityDepartment of Neurology, Thomas Jefferson University

关键词: stroke;    hypertension;    cerebral edema;    intracranial pressure;    neurological intensive care;    intensive care;    neurocritical care;    Novel Therapies for Intracerebral Hemorrhage;    JHN;    Thomas Jefferson University;   

DOI  :  

学科分类：农业科学（综合）

来源: Thomas Jefferson University * Department of Neurological Surgery

【 摘 要 】

INTRODUCTION Intracerebral hemorrhage is by far the most destructive form of stroke1. Apart from the management in a specialized stroke or neurological intensive care unit (NICU), no specific therapies have been shown to consistently improve outcomes after ICH2. Current Guidelines endorse early aggressive optimization of physiologic derangements with ventilatory support when indicated, blood pressure control, reversal of any preexisting coagulopathy, intracranial pressure monitoring for certain cases, osmotherapy, temperature modulation, seizure prophylaxis, treatment of hyerglycemia, and nutritional support in the stroke unit or NICU. Ventriculostomy is the cornerstone of therapy for control of intracranial pressure patients with intraventricular hemorrhage. 3, 4 Surgical hematoma evacuation does not improve outcome for most patients, but is a reasonable option for patients with early worsening due to mass effect due to large cerebellar or lobar hemorrhages. Promising experimental treatments involve targeting of molecular mechanisms implicated in inflammation, blood product degradation, and secondary neuronal damage.Pages: 11-14.

【 授权许可】

Unknown