A randomized, open, multicenter clinical study on the short course of intravenous infusion of 750 mg of levofloxacin and the sequential standard course of intravenous infusion/oral administration of 500 mg of levofloxacin for treatment of community-acquired pneumonia

Journal of Thoracic Disease

Jin Chen⁸  Tiemei Zhao^1,14  Guizhen Tian^1,13  Weidong Song⁷  Bei He²  Dongxia Wang^1,16  Ping Wang^1,17  Youning Liu^1,14  Ping Chen³  Baiying Zhang⁹  Liang-An Chen^1,14  Zhijie Pan⁴  Xingyi Zhang^1,11  Changzhou Shao⁶  Huili Zhu^1,12  Xiwen Gao⁵  Zhancheng Gao^1,15  Zhijun Jie^1,10  Feng Ye¹ 

[1] Respiratory Department of the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, ChinaRespiratory Department of the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, ChinaRespiratory Department of the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China;Respiratory Department of Peking University Third Hospital, Beijing 100191, ChinaRespiratory Department of Peking University Third Hospital, Beijing 100191, ChinaRespiratory Department of Peking University Third Hospital, Beijing 100191, China;Respiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Luwan Branch of Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200020, ChinaRespiratory Department of Second Xiangya Hospital of Central South University, Changsha 410011, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Luwan Branch of Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200020, ChinaRespiratory Department of Second Xiangya Hospital of Central South University, Changsha 410011, ChinaRespiratory Department of Luwan Branch of Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200020, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Luwan Branch of Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200020, ChinaRespiratory Department of Second Xiangya Hospital of Central South University, Changsha 410011, ChinaRespiratory Department of Second Xiangya Hospital of Central South University, Changsha 410011, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Luwan Branch of Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200020, ChinaRespiratory Department of Second Xiangya Hospital of Central South University, Changsha 410011, China;Respiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the 263th Hospital of Chinese PLA, Beijing 101149, ChinaRespiratory Department of the First Affiliated Hospital of Zhejiang University, Hangzhou 310003, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the 263th Hospital of Chinese PLA, Beijing 101149, ChinaRespiratory Department of the First Affiliated Hospital of Zhejiang University, Hangzhou 310003, ChinaRespiratory Department of the 263th Hospital of Chinese PLA, Beijing 101149, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the 263th Hospital of Chinese PLA, Beijing 101149, ChinaRespiratory Department of the First Affiliated Hospital of Zhejiang University, Hangzhou 310003, ChinaRespiratory Department of the First Affiliated Hospital of Zhejiang University, Hangzhou 310003, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the 263th Hospital of Chinese PLA, Beijing 101149, ChinaRespiratory Department of the First Affiliated Hospital of Zhejiang University, Hangzhou 310003, China;Respiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the Central Hospital of Minhang District, Shanghai Ruijin Hospital Group, Shanghai 201100, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the Central Hospital of Minhang District, Shanghai Ruijin Hospital Group, Shanghai 201100, ChinaRespiratory Department of the Central Hospital of Minhang District, Shanghai Ruijin Hospital Group, Shanghai 201100, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the Central Hospital of Minhang District, Shanghai Ruijin Hospital Group, Shanghai 201100, China;Respiratory Department of Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaRespiratory Department of Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaRespiratory Department of Zhongshan Hospital, Fudan University, Shanghai 200032, China;Respiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the 306th Hospital of Chinese PLA, Beijing 100101, ChinaRespiratory Department of Peking University Shenzhen Hospital, Shenzhen 518036, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the 306th Hospital of Chinese PLA, Beijing 100101, ChinaRespiratory Department of Peking University Shenzhen Hospital, Shenzhen 518036, ChinaRespiratory Department of the 306th Hospital of Chinese PLA, Beijing 100101, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the 306th Hospital of Chinese PLA, Beijing 100101, ChinaRespiratory Department of Peking University Shenzhen Hospital, Shenzhen 518036, ChinaRespiratory Department of Peking University Shenzhen Hospital, Shenzhen 518036, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the 306th Hospital of Chinese PLA, Beijing 100101, ChinaRespiratory Department of Peking University Shenzhen Hospital, Shenzhen 518036, China;Respiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, ChinaRespiratory Department of Fuxing Hospital Affiliated to Capital Medical University, Beijing 100038, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, ChinaRespiratory Department of Fuxing Hospital Affiliated to Capital Medical University, Beijing 100038, ChinaRespiratory Department of the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, ChinaRespiratory Department of Fuxing Hospital Affiliated to Capital Medical University, Beijing 100038, ChinaRespiratory Department of Fuxing Hospital Affiliated to Capital Medical University, Beijing 100038, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, ChinaRespiratory Department of Fuxing Hospital Affiliated to Capital Medical University, Beijing 100038, China;Respiratory Department of Luwan Branch of Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200020, ChinaRespiratory Department of Luwan Branch of Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200020, ChinaRespiratory Department of Luwan Branch of Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200020, China;Respiratory Department of Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, ChinaRespiratory Department of Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, ChinaRespiratory Department of Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China;Respiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Huadong Hospital Affiliated to Fudan University, Shanghai 200040, ChinaRespiratory Department of the First Affiliated Hospital of Shanghai Jiaotong University, Shanghai 200080, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Huadong Hospital Affiliated to Fudan University, Shanghai 200040, ChinaRespiratory Department of the First Affiliated Hospital of Shanghai Jiaotong University, Shanghai 200080, ChinaRespiratory Department of Huadong Hospital Affiliated to Fudan University, Shanghai 200040, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Huadong Hospital Affiliated to Fudan University, Shanghai 200040, ChinaRespiratory Department of the First Affiliated Hospital of Shanghai Jiaotong University, Shanghai 200080, ChinaRespiratory Department of the First Affiliated Hospital of Shanghai Jiaotong University, Shanghai 200080, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Huadong Hospital Affiliated to Fudan University, Shanghai 200040, ChinaRespiratory Department of the First Affiliated Hospital of Shanghai Jiaotong University, Shanghai 200080, China;Respiratory Department of Huadong Hospital Affiliated to Fudan University, Shanghai 200040, ChinaRespiratory Department of Huadong Hospital Affiliated to Fudan University, Shanghai 200040, ChinaRespiratory Department of Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China;Respiratory Department of the 263th Hospital of Chinese PLA, Beijing 101149, ChinaRespiratory Department of the 263th Hospital of Chinese PLA, Beijing 101149, ChinaRespiratory Department of the 263th Hospital of Chinese PLA, Beijing 101149, China;Respiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, China;Respiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Peking University Third Hospital, Beijing 100191, ChinaRespiratory Department of Peking University People’s Hospital, Beijing 100044, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Peking University Third Hospital, Beijing 100191, ChinaRespiratory Department of Peking University People’s Hospital, Beijing 100044, ChinaRespiratory Department of Peking University Third Hospital, Beijing 100191, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Peking University Third Hospital, Beijing 100191, ChinaRespiratory Department of Peking University People’s Hospital, Beijing 100044, ChinaRespiratory Department of Peking University People’s Hospital, Beijing 100044, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Peking University Third Hospital, Beijing 100191, ChinaRespiratory Department of Peking University People’s Hospital, Beijing 100044, China;Respiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the PLA Second Artillery General Hospital, Beijing 100088, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the PLA Second Artillery General Hospital, Beijing 100088, ChinaRespiratory Department of the PLA Second Artillery General Hospital, Beijing 100088, ChinaRespiratory Department of Chinese PLA General Hospital, Beijing 100853, ChinaRespiratory Department of the PLA Second Artillery General Hospital, Beijing 100088, China;Respiratory Department of the 306th Hospital of Chinese PLA, Beijing 100101, ChinaRespiratory Department of the 306th Hospital of Chinese PLA, Beijing 100101, ChinaRespiratory Department of the 306th Hospital of Chinese PLA, Beijing 100101, China

关键词: Community-acquired pneumonia (CAP);    levofloxacin;    effectiveness;    safety;   

DOI  :  10.21037/jtd.2016.08.30

学科分类：呼吸医学

来源: Pioneer Bioscience Publishing Company

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