Genetic Architecture of Variation in the Lateral Line Sensory System of Threespine Sticklebacks

G3: Genes, Genomes, Genetics

Richard M. Myers¹  Lam-Ha Dang⁴  Jane Grimwood¹  Abigail R. Wark²  Shannon D. Brady³  Jeremy Schmutz¹  Catherine L. Peichel⁴  Devin M. Absher¹  David M. Kingsley³  Felicity C. Jones³  Margaret G. Mills⁵  Yingguang Frank Chan³ 

[1] HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806;Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, Washington 98195Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, Washington 98195Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, Washington 98195Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, Washington 98195;Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University, Stanford, California 94305Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University, Stanford, California 94305Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University, Stanford, California 94305;Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109;Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, Washington 98195Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, Washington 98195Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, Washington 98195Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, Washington 98195

关键词: sensory system;    evolution;    lateral line;    lateral plates;    QTL mapping;   

DOI  :  10.1534/g3.112.003079

学科分类：生物科学（综合）

来源: Genetics Society of America

【 摘 要 】

Vertebrate sensory systems have evolved remarkable diversity, but little is known about the underlying genetic mechanisms. The lateral line sensory system of aquatic vertebrates is a promising model for genetic investigations of sensory evolution because there is extensive variation within and between species, and this variation is easily quantified. In the present study, we compare the lateral line sensory system of threespine sticklebacks (Gasterosteus aculeatus) from an ancestral marine and a derived benthic lake population. We show that lab-raised individuals from these populations display differences in sensory neuromast number, neuromast patterning, and groove morphology. Using genetic linkage mapping, we identify regions of the genome that influence different aspects of lateral line morphology. Distinct loci independently affect neuromast number on different body regions, suggesting that a modular genetic structure underlies the evolution of peripheral receptor number in this sensory system. Pleiotropy and/or tight linkage are also important, as we identify a region on linkage group 21 that affects multiple aspects of lateral line morphology. Finally, we detect epistasis between a locus on linkage group 4 and a locus on linkage group 21; interactions between these loci contribute to variation in neuromast pattern. Our results reveal a complex genetic architecture underlying the evolution of the stickleback lateral line sensory system. This study further uncovers a genetic relationship between sensory morphology and non-neural traits (bony lateral plates), creating an opportunity to investigate morphological constraints on sensory evolution in a vertebrate model system.

【 授权许可】

Unknown