Genetic Analysis of Fibroblast Growth Factor Signaling in the Drosophila Eye

G3: Genes, Genomes, Genetics

I. Choi²  Utpal Banerjee³  T. Mukherjee¹ 

[1] Department of Molecular, Cell and Developmental BiologyDepartment of Molecular, Cell and Developmental BiologyDepartment of Molecular, Cell and Developmental Biology;Davis School of Gerontology, Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, California 90089-0191Davis School of Gerontology, Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, California 90089-0191Davis School of Gerontology, Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, California 90089-0191;Department of Molecular, Cell and Developmental BiologyMolecular Biology InstituteDepartment of Biological ChemistryEli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, California 90095Department of Molecular, Cell and Developmental BiologyDepartment of Molecular, Cell and Developmental BiologyMolecular Biology InstituteDepartment of Biological ChemistryEli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, California 90095Molecular Biology InstituteDepartment of Molecular, Cell and Developmental BiologyMolecular Biology InstituteDepartment of Biological ChemistryEli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, California 90095Department of Biological ChemistryDepartment of Molecular, Cell and Developmental BiologyMolecular Biology InstituteDepartment of Biological ChemistryEli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, California 90095Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, California 90095Department of Molecular, Cell and Developmental BiologyMolecular Biology InstituteDepartment of Biological ChemistryEli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, California 90095

关键词: cellular adhesion;    cadherins;    fibroblast growth factor (FGF) signaling;    morphogenetic furrow;    glial cell migration;   

DOI  :  10.1534/g3.111.001495

学科分类：生物科学（综合）

来源: Genetics Society of America

【 摘 要 】

The development of eyes in Drosophila involves intricate epithelial reorganization events for accurate positioning of cells and proper formation and organization of ommatidial clusters. We demonstrate that Branchless (Bnl), the fibroblast growth factor ligand, regulates restructuring events in the eye disc primordium from as early as the emergence of clusters from a morphogenetic front to the cellular movements during pupal eye development. Breathless (Btl) functions as the fibroblast growth factor receptor to mediate Bnl signal, and together they regulate expression of DE-cadherin, Crumbs, and Actin. In addition, in the eye Bnl regulates the temporal onset and extent of retinal basal glial cell migration by activating Btl in the glia. We hypothesized that the Bnl functions in the eye are Hedgehog dependent and represent novel aspects of Bnl signaling not explored previously.

【 授权许可】

Unknown