Improving Patient Selection for 18F-FDG PET Scanning in the Staging of Gastric Cancer

Journal of Nuclear Medicine

Yui Kaneko¹  Cuong Duong¹  Emma Link¹  William K Murray¹  Rodney J. Hicks¹ 

关键词: FDG-PET;    gastric cancer;    staging;   

DOI  :  10.2967/jnumed.114.150946

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Standard pretreatment staging for gastric cancer includes CT of the chest, abdomen, and pelvis; gastroscopy; and laparoscopy. Although 18F-PET combined with CT has proven to be a useful staging tool in many cancers, some gastric cancers are not 18F-FDG–avid and its clinical value is still debatable. Methods: Gastric cancer patients who underwent staging 18F-FDG PET scans from 2002 to 2013 at the Peter MacCallum Cancer Center were retrospectively analyzed, and a systematic review was also conducted using PubMed between 2000 to March 2014 to investigate clinicopathologic parameters associated with 18F-FDG avidity. A pretreatment PET scoring system was developed from predictors of 18F-FDG avidity. Results: Both the retrospective analysis of the patients and the systematic literature review showed similar significant predictors of 18F-FDG avidity, including large tumor size, non–signet ring cell carcinoma type, and glucose transporter 1–positive expression on immunohistochemistry. A PET scoring system was developed from these clinicopathologic parameters that allowed 18F-FDG–avid tumors to be detected with a sensitivity of 85% and a specificity of 71%. Conclusion: A pretreatment PET scoring system can assist in the selection of patients with gastric adenocarcinoma when staging 18F-FDG PET is being considered.

【 授权许可】

Unknown