Correlation of 68Ga Ventilation–Perfusion PET/CT with Pulmonary Function Test Indices for Assessing Lung Function

Journal of Nuclear Medicine

Pierre-Yves Le Roux¹  Lou B. Irving¹  Daniel P. Steinfort¹  Jason Callahan¹  Michael S. Hofman¹  Peter Eu¹  Rodney J. Hicks¹  Shankar Siva¹ 

关键词: PET/CT;    ventilation;    perfusion;    pulmonary function tests;    chronic obstructive pulmonary disease;   

DOI  :  10.2967/jnumed.115.162586

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Pulmonary function tests (PFTs) are routinely used to assess lung function, but they do not provide information about regional pulmonary dysfunction. We aimed to assess correlation of quantitative ventilation–perfusion (V/Q) PET/CT with PFT indices. Methods: Thirty patients underwent V/Q PET/CT and PFT. Respiration-gated images were acquired after inhalation of 68Ga-carbon nanoparticles and administration of 68Ga-macroaggregated albumin. Functional volumes were calculated by dividing the volume of normal ventilated and perfused (%NVQ), unmatched and matched defects by the total lung volume. These functional volumes were correlated with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, and diffusing capacity for carbon monoxide (DLCO). Results: All functional volumes were significantly different in patients with chronic obstructive pulmonary disease (P < 0.05). FEV1/FVC and %NVQ had the highest correlation (r = 0.82). FEV1 was also best correlated with %NVQ (r = 0.64). DLCO was best correlated with the volume of unmatched defects (r = −0.55). Considering %NVQ only, a cutoff value of 90% correctly categorized 28 of 30 patients with or without significant pulmonary function impairment. Conclusion: Our study demonstrates strong correlations between V/Q PET/CT functional volumes and PFT parameters. Because V/Q PET/CT is able to assess regional lung function, these data support the feasibility of its use in radiation therapy and preoperative planning and assessing pulmonary dysfunction in a variety of respiratory diseases.

【 授权许可】

Unknown