Fat-Constrained 18F-FDG PET Reconstruction in Hybrid PET/MR Imaging

Journal of Nuclear Medicine

Susanne Heinzer¹  Osman Ratib¹  Christian Wülker¹  Peter Börnert¹  Steffen Renisch¹  Sven Prevrhal¹ 

关键词: PET/MR;    fat tissue;    Dixon;    PET reconstruction;    prior information;   

DOI  :  10.2967/jnumed.114.139758

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Fusion of information from PET and MR imaging can increase the diagnostic value of both modalities. This work sought to improve 18F FDG PET image quality by using MR Dixon fat-constrained images to constrain PET image reconstruction to low-fat regions, with the working hypothesis that fatty tissue metabolism is low in glucose consumption. Methods: A novel constrained PET reconstruction algorithm was implemented via a modification of the system matrix in list-mode time-of-flight ordered-subsets expectation maximization reconstruction, similar to the way time-of-flight weighting is incorporated. To demonstrate its use in PET/MR imaging, we modeled a constraint based on fat/water-separating Dixon MR images that shift activity away from regions of fat tissue during PET image reconstruction. PET and MR imaging scans of a modified National Electrical Manufacturers Association/International Electrotechnical Commission body phantom simulating body fat/water composition and in vivo experiments on 2 oncology patients were performed on a commercial time-of-flight PET/MR imaging system. Results: Fat-constrained PET reconstruction visibly and quantitatively increased resolution and contrast between high-uptake and fatty-tissue regions without significantly affecting the images in nonfat regions. Conclusion: The incorporation of MR tissue information, such as fat, in image reconstruction can improve the quality of PET images. The combination of a variety of potential other MR tissue characteristics with PET represents a further justification for merging MR data with PET data in hybrid systems.

【 授权许可】

Unknown