Hyperpolarized 13C MR for Molecular Imaging of Prostate Cancer

Journal of Nuclear Medicine

David M. Wilson¹  John Kurhanewicz¹ 

[1] Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California

关键词: PET/MR imaging;    PET/MRI;    ¹³C-magnetic resonance;    prostate;    prostate cancer;    hyperpolarized ¹³C;    metabolism;   

DOI  :  10.2967/jnumed.114.141705

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Hyperpolarization using dissolution dynamic nuclear polarization has emerged as a versatile method to dramatically improve the MR signal of low-sensitivity nuclei. This technique facilitates the study of real-time metabolism in vitro and in vivo using 13C-enriched substrates and has been applied to numerous models of human disease. In particular, several mechanisms underlying prostate cancer have been interrogated using hyperpolarized 13C MR spectroscopy. This review highlights key metabolic shifts seen in prostate cancer, their study by hyperpolarized 13C MR spectroscopy, and the development of new platforms for metabolic study.

【 授权许可】

Unknown