Appropriate Use Criteria for Amyloid PET: A Report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer’s Association

Journal of Nuclear Medicine

Peter Herscovitch¹  Kevin J. Donohoe¹  Maria C. Carrillo¹  Norman L. Foster¹  Satoshi Minoshima¹  Virginia Pappas¹  Nicolaas I. Bohnen¹  Christopher C. Rowe¹  Keith A. Johnson¹  Saima Hedrick¹  Jason H. Karlawish¹  William H. Thies¹  Dean M. Hartley¹ 

关键词: guidelines;    AUC;    imaging;    amyloid;    MCI;    Alzheimer’s;    PET;    florbetapir;    biomarker;    beta-amyloid;    dementia;    radiopharmaceutical;   

DOI  :  10.2967/jnumed.113.120618

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Positron emission tomography (PET) of brain amyloid β is a technology that is becoming more available, but its clinical utility in medical practice requires careful definition. To provide guidance to dementia care practitioners, patients, and caregivers, the Alzheimer’s Association and the Society of Nuclear Medicine and Molecular Imaging convened the Amyloid Imaging Taskforce (AIT). The AIT considered a broad range of specific clinical scenarios in which amyloid PET could potentially be used appropriately. Peer-reviewed, published literature was searched to ascertain available evidence relevant to these scenarios, and the AIT developed a consensus of expert opinion. Although empirical evidence of impact on clinical outcomes is not yet available, a set of specific appropriate use criteria (AUC) were agreed on that define the types of patients and clinical circumstances in which amyloid PET could be used. Both appropriate and inappropriate uses were considered and formulated, and are reported and discussed here. Because both dementia care and amyloid PET technology are in active development, these AUC will require periodic reassessment. Future research directions are also outlined, including diagnostic utility and patient-centered outcomes.

【 授权许可】

Unknown