18F-FDG PET/MRI Can Be Used to Identify Injured Peripheral Nerves in a Model of Neuropathic Pain

Journal of Nuclear Medicine

Subrat Behera¹  Sandip Biswal¹  Deepak Behera¹  Kathleen E. Jacobs¹  Jarrett Rosenberg¹ 

[1] Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, California Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, California Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, California

关键词: PET/MRI;    neuropathic pain;    ¹⁸F-FDG;    spared nerve injury;   

DOI  :  10.2967/jnumed.110.084731

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

We demonstrated increased 18F-FDG uptake in injured peripheral nerves in a model of neuropathic pain using small-animal PET/MRI. Methods: A neuropathic pain model in rats was created by spared-nerve injury of the left sciatic nerve. Sham-operated rats without nerve injury were used as a control. The presence of pain was confirmed by testing for allodynia. Sequential small-animal 18F-FDG PET and MRI scans of the thighs were obtained and coregistered. Autoradiography was performed on harvested nerves and muscle. Results: The group with spared-nerve injury showed the development of allodynia in the operated limb (P < 0.001). Increased 18F-FDG uptake was observed on both PET/MRI (P < 0.001) and autoradiography (P < 0.005) in the operated nerve in this group. 18F-FDG uptake in the nerves correlated well with allodynia (ρ = −0.59; P < 0.024). Conclusion: Animals with neuropathic pain show increased 18F-FDG uptake in the affected nerve. Small-animal PET/MRI can be effectively used to localize 18F-FDG uptake in peripheral nerves.

【 授权许可】

Unknown