Shortened Acquisition Protocols for the Quantitative Assessment of the 2-Tissue-Compartment Model Using Dynamic PET/CT 18F-FDG Studies

Journal of Nuclear Medicine

Caixia Cheng¹  Leyun Pan¹  Uwe Haberkorn¹  Ludwig G. Strauss¹  Antonia Dimitrakopoulou-Strauss¹ 

关键词: PET;    ¹⁸F-FDG;    compartment modeling;    quantification;   

DOI  :  10.2967/jnumed.110.079798

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

18F-FDG kinetics are quantified by a 2-tissue-compartment model. The routine use of dynamic PET is limited because of this modality's 1-h acquisition time. We evaluated shortened acquisition protocols up to 0–30 min regarding the accuracy for data analysis with the 2-tissue-compartment model. Methods: Full dynamic series for 0–60 min were analyzed using a 2-tissue-compartment model. The time–activity curves and the resulting parameters for the model were stored in a database. Shortened acquisition data were generated from the database using the following time intervals: 0–10, 0–16, 0–20, 0–25, and 0–30 min. Furthermore, the impact of adding a 60-min uptake value to the dynamic series was evaluated. The datasets were analyzed using dedicated software to predict the results of the full dynamic series. The software is based on a modified support vector machines (SVM) algorithm and predicts the compartment parameters of the full dynamic series. Results: The SVM-based software provides user-independent results and was accurate at predicting the compartment parameters of the full dynamic series. If a squared correlation coefficient of 0.8 (corresponding to 80% explained variance of the data) was used as a limit, a shortened acquisition of 0–16 min was accurate at predicting the 60-min 2-tissue-compartment parameters. If a limit of 0.9 (90% explained variance) was used, a dynamic series of at least 0–20 min together with the 60-min uptake values is required. Conclusion: Shortened acquisition protocols can be used to predict the parameters of the 2-tissue-compartment model. Either a dynamic PET series of 0–16 min or a combination of a dynamic PET/CT series of 0–20 min and a 60-min uptake value is accurate for analysis with a 2-tissue-compartment model.

【 授权许可】

Unknown