Internal Pair Production of 90Y Permits Hepatic Localization of Microspheres Using Routine PET: Proof of Concept

Journal of Nuclear Medicine

Riad Salem¹  Abdulredha A.H. Esmail¹  Stewart Spies¹  Vanessa L. Gates¹  Karen Marshall¹ 

关键词: hepatocellular carcinoma;    radiotherapy;    radioembolization;    ⁹⁰Y microspheres;    PET/CT;    bremsstrahlung;   

DOI  :  10.2967/jnumed.110.080986

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Radioembolization with 90Y microspheres represents a novel transarterial radiation treatment for liver tumors. The purpose of this pilot study was to evaluate the findings of postimplantation PET/CT of 90Y glass microspheres. Methods: Three patients with hepatocellular carcinoma and 2 patients with liver metastases (1 neuroendocrine, 1 colorectal) underwent PET/CT after radioembolization. Four patients underwent imaging at 1 mo to assess response and confirm PET/CT findings; 1 patient underwent PET/CT at 4 d after 90Y implantation. Patients were followed for adverse events. Results: Standard PET/CT enabled the localization of 90Y glass microspheres for all patients. None of the patients experienced adverse events related to nontarget deposition. Conclusion: Standard PET/CT may be used to assess the localization of 90Y glass microspheres. This approach provides a simple, rapid, and universally applicable method of confirming microsphere deposition. With further validation, this technique may potentially become the standard of care for confirming microsphere distribution.

【 授权许可】

Unknown