MIRD Pamphlet No. 22 (Abridged): Radiobiology and Dosimetry of α-Particle Emitters for Targeted Radionuclide Therapy

Journal of Nuclear Medicine

A. Bertrand Brill¹  Gamal Akabani¹  Roger W. Howell¹  Stig Palm¹  Darrell R. Fisher¹  Barry J. Allen¹  Hong Song¹  Michael R. McDevitt¹  George Sgouros¹  John C. Roeske¹ 

关键词: α-particle emitters;    human α-particle emitter dosimetry;    targeted α-particle emitter therapy;   

DOI  :  10.2967/jnumed.108.058651

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

The potential of α-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of α-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with α-particle emitters. Although α-emitters have been studied for many decades, their current use in humans for targeted therapy is an important milestone. The objective of this work is to review those aspects of the field that are pertinent to targeted α-particle emitter therapy and to provide guidance and recommendations for human α-particle emitter dosimetry.

【 授权许可】

Unknown