In Vivo Imaging of Macrophage Activity in the Coronary Arteries Using 68Ga-DOTATATE PET/CT: Correlation with Coronary Calcium Burden and Risk Factors

Journal of Nuclear Medicine

Alexander Haug¹  Tobias Saam¹  Konstantin Nikolaou¹  Paul Cumming¹  Marcus Hacker¹  Peter Bartenstein¹  Stefan Förster¹  Maximilian F. Reiser¹  Axel Rominger¹  Christopher Übleis¹  Eva Vogl¹  Christian la Fougère¹ 

关键词: atherosclerosis;    plaque imaging;    ⁶⁸Ga-DOTATATE PET/CT;    cardiovascular;    coronary arteries;   

DOI  :  10.2967/jnumed.109.070672

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

We measured the uptake of the somatostatin receptor ligand 68Ga-[1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″-tetraacetic acid]-d-Phe1,Tyr3-octreotate (DOTATATE) in the left anterior descending coronary artery (LAD) in association with calcified plaques (CPs) and cardiovascular risk factors. Methods: Seventy consecutive tumor patients were examined by whole-body 68Ga-DOTATATE contrast-enhanced PET/CT. Blood-pool–corrected standardized uptake value (target-to-background ratio) was measured in the LAD, and CT images were used to detect CP. Cardiovascular risk factors and history of prior cardiovascular events were recorded. Results: 68Ga-DOTATATE uptake was detectable in the LAD of all patients. Target-to-background ratio in the LAD correlated significantly with the presence of CP (R = 0.34; P < 0.01), prior vascular events (R = 0.26; P < 0.05), and male sex (R = 0.29; P < 0.05), whereas CP correlated with these parameters but also with age (R = 0.34; P < 0.01) and hypertension (R = 0.25; P < 0.05). Conclusion: In a series of oncologic patients, those with prior cardiovascular events and calcified atherosclerotic plaques showed significantly increased 68Ga-DOTATATE uptake in the LAD, suggesting a potential role of this tracer for plaque imaging in the coronary arteries.

【 授权许可】

Unknown