Endothelial Dysfunction in Systemic Lupus Erythematosus: Evaluation with 13N-Ammonia PET

Journal of Nuclear Medicine

Rodrigo Calleja¹  John O. Prior¹  Aloha Meave¹  Carlos Posadas-Romero¹  Erick Alexánderson¹  Edgar Romero¹  Juan G. Juárez-Rojas¹  Rodrigo Jácome¹  Juan M. Ochoa¹ 

关键词: ¹³N-ammonia PET;    endothelium-dependent vasodilatation index;    endothelial dysfunction;    MFR;    systemic lupus erythematosus;   

DOI  :  10.2967/jnumed.110.078212

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Systemic lupus erythematosus (SLE) affects multiple organs and systems, severely involving the cardiovascular system. The aim of this study was to evaluate the presence of endothelial dysfunction with 13N-ammonia PET in asymptomatic SLE patients. Methods: We enrolled 16 women with SLE and 16 healthy women. Myocardial blood flow (MBF) was quantified in a 64-slice PET/CT scanner at rest, during a cold pressor test (CPT), and during stress. Endothelium-dependent vasodilation index, %ΔMBF, and myocardial flow reserve (MFR) were calculated. Results: There were 16 women in the SLE group (mean age ± SD, 31.4 ± 8.3 y) and 16 women in the healthy control group (31.5 ± 11.1 y). Mean endothelium-dependent vasodilatation index and %ΔMBF were significantly lower in SLE patients (1.18 ± 0.55 vs. 1.63 ± 0.65, P = 0.04, and 18 ± 55 vs. 63 ± 65, P = 0.04, respectively). MFR was also lower in the SLE group (2.41 ± 0.59 vs. 2.73 ± 0.77, P = 0.20). Conclusion: SLE patients who are free of active disease present abnormal coronary flow and endothelial dysfunction. It is necessary to develop and intensify treatment strategies directed to CAD in SLE patients.

【 授权许可】

Unknown