Vascular Inflammation Imaging with 18F-FDG PET/CT: When to Image?

Journal of Nuclear Medicine

Ashley M. Groves¹  Ian Cullum¹  John C. Dickson¹  Brian F. Hutton¹  Leon J. Menezes¹  Raymondo Endozo¹  Carl W. Kotze¹  Peter J. Ell¹  Syed W. Yusuf¹ 

关键词: PET/CT;    vascular;    radiotracer tissue kinetics;    ¹⁸F-FDG;    aneurysm;    atherosclerosis;    methodology;    positron emission tomography;   

DOI  :  10.2967/jnumed.108.061432

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

We prospectively investigated the ideal imaging time to measure vascular uptake after injection of 18F-FDG. Methods: A total of 17 patients with atherosclerotic abdominal aortic aneurysm underwent dynamic abdominal PET/CT using 2-min frames between 45 and 53, 57 and 65, 115 and 123, and 175 and 183 min after injection of 18F-FDG. For each period of dynamic imaging, vessel wall and lumen uptake were measured using the maximum standardized uptake value (SUVmax) and target-to-background ratio (TBR). Results: No significant difference in TBR across all time points (repeated measures ANOVA, P = 0.206) was observed, despite a significant difference in aortic wall and lumen uptake with time (repeated measures ANOVA, P = 0.02 and P < 0.001, respectively). There was no significant difference between aortic wall uptake at 60 min (SUVmax, 2.15 ± 0.11 SE) and 180 min (SUVmax, 1.99 ± 0.18 SE) (paired t test, P = 0.367). There was a significant difference in lumen uptake at 60 min (SUVmax, 2.4 ± 0.11 SE) and 180 min (SUVmax, 1.7 ± 0.1 SE) (paired t test, P = 0.001). There was no significant difference in TBR between 60 min (0.91 ± 0.03) and 180 min (1.01 ± 0.06 SE) (paired t test, P = 0.131). With increasing delayed imaging, there was increasing variability (SE) in the SUVmax for the aortic wall and TBRs. Conclusion: There was no significant advantage in imaging at 3 h over 1 h after 18F-FDG injection.

【 授权许可】

Unknown