Reference Tissue Models and Blood–Brain Barrier Disruption: Lessons from (R)-[11C]PK11195 in Traumatic Brain Injury

Journal of Nuclear Medicine

Bart N.M. van Berckel¹  W. Peter Vandertop¹  Mark Lubberink¹  Hedy Folkersma¹  Reina W. Kloet¹  Ronald Boellaard¹  Adriaan A. Lammertsma¹ 

关键词: blood–brain barrier;    craniocerebral trauma;    (R)-[¹¹C]PK11195;    humans;    positron emission tomography;   

DOI  :  10.2967/jnumed.109.067512

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

(R)-[11C]PK11195 is a tracer for activated microglia. The purpose of this study was to assess the validity of the simplified reference tissue model for analyzing (R)-[11C]PK11195 studies in traumatic brain injury (TBI), where blood–brain barrier disruptions are likely. Methods: Dynamic (R)-[11C]PK11195 scans were acquired at 3 time points after TBI. Plasma input–derived binding potential (BPNDPI), volume of distribution (VT) and K1/k2, and simplified reference tissue model–derived binding potential (BPNDSRTM) were obtained. Simulations were performed to assess the effect of varying K1/k2. Results: Early after TBI, an increase in VT, but not in BPNDPI, was found. Early K1/k2 correlated with VT and BPNDSRTM but not with BPNDPI. One and 6 mo after TBI, BPNDSRTM correlated with BPNDPI. Conclusion: Early after TBI, (R)-[11C]PK11195 studies should be analyzed using plasma input models.

【 授权许可】

Unknown