18F-Fluorodeoxythymidine PET for Evaluating the Response to Hyperthermic Isolated Limb Perfusion for Locally Advanced Soft-Tissue Sarcomas

Journal of Nuclear Medicine

Harald J. Hoekstra¹  Philip H. Elsinga¹  Pieter L. Jager¹  Lukas B. Been¹  Robert J. van Ginkel¹  Albert J.H. Suurmeijer¹ 

关键词: ¹⁸F-FLT PET;    soft-tissue sarcomas;    hyperthermic isolated limb perfusion;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Locally advanced soft-tissue sarcomas of an extremity can be treated either by amputation of the limb or by hyperthermic isolated limb perfusion (HILP) followed by resection of the tumor. In this study, the response to HILP was measured by PET with 18F-fluorodeoxythymidine (18F-FLT). Methods: Ten patients with primary nonresectable soft-tissue sarcomas of an extremity underwent HILP with tumor necrosis factor-α and melphalan. Before and after HILP, all patients underwent PET with 18F-FLT for response evaluation. Results: Before HILP, all tumors were clearly visible on 18F-FLT PET; for the maximum standardized uptake value (SUVmax), the mean was 3.5 (range, 1.0–6.7), and for the mean standardized uptake value (SUVmean), the mean was 1.9 (range, 0.7–2.7). After HILP, all but 1 tumor showed necrosis ranging from 10% to 95%. 18F-FLT PET after HILP revealed significantly decreased uptake of the tracer. The mean SUVmax decreased to 1.7 (P = 0.008), and the mean SUVmean decreased to 0.8 (P = 0.002). One small axillary lymph node metastasis was not visible on 18F-FLT PET. Conclusion: 18F-FLT PET revealed high uptake in soft-tissue sarcomas. 18F-FLT uptake was correlated with the mitotic index of the tumors (r = 0.82 and P = 0.004 for SUVmax; r = 0.87 and P = 0.001 for SUVmean). After HILP, the uptake of 18F-FLT decreased significantly (P = 0.008 and P = 0.002 for SUVmax and SUVmean, respectively). Tumors with initially high 18F-FLT uptake showed a better response to HILP (r = 0.64, P < 0.05). Software fusion of PET images with images from conventional imaging modalities revealed the heterogeneity of the tumors before and after HILP. Such data can help a surgeon in planning the resection of a tumor.

【 授权许可】

Unknown