Localization of Dystonic Muscles with 18F-FDG PET/CT in Idiopathic Cervical Dystonia

Journal of Nuclear Medicine

Byung-Tae Kim¹  Joon Young Choi¹  Du-Hwan Kim¹  Duk Hyun Sung¹  Young-Ik Son¹  Kyung-Han Lee¹  Young-Seok Cho¹  Eun-Sang Kim¹  Su Jin Lee¹ 

关键词: cervical dystonia;    spasmodic torticollis;    botulinum toxin;    ¹⁸F-FDG PET/CT;   

DOI  :  10.2967/jnumed.107.044024

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

The purpose of this study was to investigate whether 18F-FDG PET/CT is useful for localizing dystonic cervical muscles in patients with idiopathic cervical dystonia (ICD) by comparing disease severity before and disease severity after botulinum toxin (BT) injection into hypermetabolic muscles. Methods: Six patients with ICD underwent 18F-FDG PET/CT. Dystonic muscles suitable for BT injection therapy were defined as those showing diffusely increased 18F-FDG uptake. Results: Hypermetabolic cervical muscles were identified in all 6 patients. In 2 patients who underwent PET/CT both in a supine position and in a sitting position during 18F-FDG uptake, abnormal hypermetabolic muscles were observed by PET/CT only when patients were in the sitting position with their heads and necks in the adopted abnormal involuntary posture. Symptoms were significantly improved in 4 patients who underwent BT injection therapy guided by PET/CT and who were clinically monitored. Conclusion: 18F-FDG PET/CT is potentially useful for identifying dystonic cervical muscles for BT therapy in patients with ICD.

【 授权许可】

Unknown