Radiation Dose Distribution in Human Kidneys by Octreotides in Peptide Receptor Radionuclide Therapy

Journal of Nuclear Medicine

Roelf Valkema¹  Eric Krenning¹  Marleen Melis¹  Mark Konijnenberg¹  Marion de Jong¹ 

关键词: kidney dosimetry;    dose volume histogram;    ⁹⁰Y-DOTA-octreotide;    ¹¹¹In-DTPA-octreotide;    ¹⁷⁷Lu-DOTA-octreotate;    radionuclide therapy;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Ex vivo autoradiographs of healthy kidney tissue from patients who received 111In-DTPA-octreotide (DTPA is diethylenetriaminepentaacetic acid) before nephrectomy showed very heterogeneous radioactivity patterns in the kidneys. The consequences of the reported inhomogeneities have been evaluated for radionuclide therapy with 90Y- DOTA-Tyr3-octreotide (DOTA is 1,4,7,10-tetraazacyclododecane-N,N′,N′′,N′′′-tetraacetic acid), 177Lu-DOTA-Tyr3-octreotate, and 111In-DTPA-octreotide by calculating dose distributions and dose−volume histograms (DVHs) for the kidneys. Methods: Monte Carlo radiation transport calculations were performed by using the MCNP code version 5. The autoradiography data were used in a 2-dimensional model of the kidney tissue sections. A voxel structure inside the MIRD Pamphlet 19 multiregion kidney model was developed to generate a 3-dimensional representation of the autoradiographs. Dose distributions were calculated for the β-emitter 90Y, the low-energy electron and γ-emitter 111In, and the β- and γ-emitter 177Lu. Isodose curves were generated for the 2-dimensional kidney sections and DVHs for the 3-dimensional kidney model. Results: The isodose curves for the high-energy β-emitter 90Y did not show a sign of the inhomogeneous activity distribution, apart from the cortex−medulla boundaries. Both 111In and 177Lu isodose curves follow the autoradiographic activity distribution exactly. The 2 γ-rays from 111In give higher doses to the low-radioactivity regions in the kidney sections. The DVHs show that the inhomogeneous activity distribution creates considerable volumes within the kidney and within the cortex with lower doses than the average kidney dose, together with volumes receiving much higher doses. This effect is most profound for 177Lu, but also 111In shows this heterogeneity in the dose distribution. Conclusion: Kidney dosimetry for radionuclide therapy can be based on average MIRD-based dose models for high-energy β-emitters (such as 90Y). In contrast, low-energy β-emitters (such as 177Lu) and Auger-electron−emitting radionuclides (such as 111In) produce dose distributions in the kidneys that are very dependent on the activity distribution pattern in the kidney or renal cortex. Complication probability models for renal tissue damage after radionuclide therapy with these latter nuclides need to be developed, as the existing models based on average dose to the kidney or cortex from external beam therapy experience are most probably not valid.

【 授权许可】

Unknown