Dosimetry in Peptide Radionuclide Receptor Therapy: A Review

Journal of Nuclear Medicine

Giampiero Tosi¹  Lisa Bodei¹  Marta Cremonesi¹  Giovanni Paganelli¹  Mahila Ferrari¹ 

关键词: dosimetry;    peptide receptor radionuclide therapy;    ¹¹¹In;    ⁹⁰Y;    ¹⁷⁷Lu;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

The potential of targeted therapy with radiolabeled peptides has been reported in several clinical trials. Although there have been many improvements in dose estimation, a general and reliable dosimetric approach in peptide receptor radionuclide therapy (PRRT) is still a matter of debate. This article reviews the methods for PRRT dosimetry and the results presented in the literature. Radiopharmaceutical characteristics, data processing, dosimetric outcomes, and methods to protect critical organs are reported. The biological effective dose, based on the linear quadratic model, is also described.

【 授权许可】

Unknown