Iodine Biokinetics and Dosimetry in Radioiodine Therapy of Thyroid Cancer: Procedures and Results of a Prospective International Controlled Study of Ablation After rhTSH or Hormone Withdrawal

Journal of Nuclear Medicine

Markus Luster¹  Claudia Ceccarelli¹  Christoph Reiners¹  Martin Schlumberger¹  Carine Corone¹  Paul W. Ladenson¹  Michael Lassmann¹  Heribert Hänscheid¹  Al Driedger¹  Richard L. Wahl¹  Bryan R. Haugen¹  Furio Pacini¹  Vincent Carriere¹  Richard T. Kloos¹  Marcel Ricard¹  Stephen R. Thomas¹  Steven I. Sherman¹ 

关键词: differentiated thyroid cancer;    radioiodine therapy;    rhTSH;    blood dose;    dosimetry;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Technical aspects and results of the dosimetric assessments of postoperative radioiodine ablation in the framework of an international, prospective, controlled, randomized, comparative study of the effectiveness of ablation therapy with 3.7 GBq 131I in differentiated thyroid cancer after stimulation with recombinant human TSH (rhTSH) or by thyroid hormone withdrawal (THW) are presented. Methods: Sixty-three patients were randomized after thyroidectomy to either the THW or the rhTSH group. Scintigraphic neck images were acquired starting 48 h after radioiodine administration to assess biokinetics in the thyroid remnant. The activity in blood samples was quantified and data from whole-body probe measurements and scintigraphic whole-body scans were combined to deduce retention curves in blood and whole body, respectively. The absorbed dose to the blood was calculated using a modified approach based on the formalism of the MIRD Committee of the Society of Nuclear Medicine. Results: The effective half-time in the remnant thyroid tissue was significantly longer after rhTSH than THW (67.6 ± 48.8 vs. 48.0 ± 52.6 h, respectively; P = 0.01), whereas the observed differences of the mean 48-h 131I uptakes (0.5% ± 0.7% vs. 0.9% ± 1.0% after THW; P = 0.1) and residence times (0.9 ± 1.3 vs. 1.4 ± 1.5 h after THW; P = 0.1) between the rhTSH and THW groups were not statistically significant. The specific absorbed dose to the blood was significantly (P <0.0001) lower after administration of rhTSH (mean, 0.109 ± 0.028 mGy/MBq; maximum, 0.18 mGy/MBq) than after THW (mean, 0.167 ± 0.061 mGy/MBq; maximum, 0.35 mGy/MBq), indicating that higher activities of radioiodine might be safely administered after exogenous stimulation with rhTSH. Conclusion: Indication of an influence of the residence time of radioiodine in the blood on the fractional uptake into thyroid remnant was found. A novel regimen is proposed in which therapeutic activities to be administered are determined from the individual specific blood dose.

【 授权许可】

Unknown