Diagnosis of Misery Perfusion Using Noninvasive 15O-Gas PET

Journal of Nuclear Medicine

Hidehiko Okazawa¹  Tatsuro Tsuchida¹  Masato Kobayashi¹  Keiichi Kawai¹  Yasuhisa Fujibayashi¹  Yoshiharu Yonekura¹ 

关键词: oxygen extraction fraction;    misery perfusion;    gas PET study;    noninvasive method;    cerebrovascular disease;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

To avoid arterial blood sampling and complicated analyses in 15O-gas PET studies, we evaluated a noninvasive technique using the count-based method for measuring asymmetric increases in oxygen extraction fraction (OEF) in cerebrovascular disease. Methods: Eighteen patients (mean age ± SD, 61 ± 16 y) with atherothrombotic large-cerebral-artery disease were studied for the measurement of hemodynamic parameters using the 15O-gas steady-state method with inhalation of 15O2, C15O2, and C15O. All patients also underwent H215O PET with the bolus injection method. Count-based ratio images of 15O2/C15O2 and 15O2/H215O were calculated, and asymmetry indices (AIs) were obtained (cbOEFSS-AI and cbOEFBO-AI, respectively) using regions of interest drawn bilaterally on the cerebral cortices. These AIs were compared with the AIs of absolute OEF (qOEF-AI) and with those after cerebral blood volume (CBV) correction. A contribution factor for this correction was defined as a variable α, and the effect of the correction was evaluated. Results: cbOEFSS-AI underestimated qOEF-AI significantly, especially with a greater AI (P < 0.05). cbOEFBO-AI linearly correlated well with qOEF-AI. CBV correction improved the slopes of regression lines between qOEF-AI and cbOEFSS-AI, and the optimal α was defined as 0.5. On the other hand, cbOEFBO-AI fairly estimated qOEF-AI without CBV correction. Correlation between qOEF-AI and cbOEFBO-AI was adversely affected, and the mean bias was increased, with a greater α. Conclusion: cbOEFBO-AI can fairly estimate the AI of OEF without CBV correction, whereas cbOEFSS-AI might require CBV correction for better estimation. The examination time and stress to patients would be reduced with the count-based method because it is noninvasive.

【 授权许可】

Unknown