Whole-Body Biodistribution and Estimation of Radiation-Absorbed Doses of the Dopamine D1 Receptor Radioligand 11C-NNC 112 in Humans

Journal of Nuclear Medicine

Jinsoo Hong¹  Robert B. Innis¹  Subroto Ghose¹  Victor W. Pike¹  Vanessa L. Cropley¹  Pradeep J. Nathan¹  Janet Sangare¹  John L. Musachio¹  Masahiro Fujita¹ 

关键词: ¹¹C-NNC 112;    PET;    D₁ receptor;    dosimetry;    effective dose;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

The present study estimated radiation-absorbed doses of the dopamine D1 receptor radioligand [11C]((+)-8-chloro-5-(7-benzofuranyl)-7-hydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine) (NNC 112) in humans, based on dynamic whole-body PET in healthy subjects. Methods: Whole-body PET was performed on 7 subjects after injection of 710 ± 85 MBq of 11C-NNC 112. Fourteen frames were acquired for a total of 120 min in 7 segments of the body. Regions of interest were drawn on compressed planar images of source organs that could be identified. Radiation dose estimates were calculated from organ residence times using the OLINDA 1.0 program. Results: The organs with the highest radiation-absorbed doses were the gallbladder, liver, lungs, kidneys, and urinary bladder wall. Biexponential fitting of mean bladder activity demonstrated that 15% of activity was excreted via the urine. With a 2.4-h voiding interval, the effective dose was 5.7 μSv/MBq (21.1 mrem/mCi). Conclusion: 11C-NNC 112 displays a favorable radiation dose profile in humans and would allow multiple PET examinations per year to be performed on the same subject.

【 授权许可】

Unknown