Gated Myocardial SPECT to Predict Response to β-Blocker Therapy in Patients with Idiopathic Dilated Cardiomyopathy

Journal of Nuclear Medicine

Yoshio Yasumura¹  Kohei Hayashida¹  Kunio Miyatake¹  Kazuki Fukuchi¹  Keisuke Kiso¹  Yoshio Ishida¹ 

关键词: gated SPECT;    dilated cardiomyopathy;    and β-blocker;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Because of the difficulty of predicting the response of patients with idiopathic dilated cardiomyopathy (IDC) to β-blocker therapy, this study was performed to evaluate whether gated myocardial SPECT (gated SPECT) could be useful for predicting that response. Methods: We performed gated SPECT with 99mTc-sestamibi on 38 patients with IDC before treatment with a β-blocker and standard medication. Perfusion abnormalities, left ventricular (LV) function, and spheric distortion were assessed by a quantitative software program. Results: We classified patients into 2 groups according to improvement in LV function after 4 mo of therapy. The groups consisted of 16 poor responders whose LV ejection fraction (LVEF) increased less than 10% and 22 good responders whose LVEF increased by 10% or more. The patient characteristics before therapy, including LV volume and LVEF, did not significantly differ between the 2 groups, but the size of the myocardial perfusion defect and spheric distortion were significantly greater in poor responders than in good responders. Conclusion: Gated SPECT, by allowing simultaneous assessment of perfusion, function and geometry, might be useful for predicting the response of patients with IDC to β-blocker therapy.

【 授权许可】

Unknown