Identification of metabolites of AHTN in rat urine and feces by liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry

Analytical Methods

Yi Yang²  Bing Shao¹  Yin Zhang¹  Jing Zhang³ 

[1] Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention,Beijing 100013,ChinaState Key Laboratory of Food Science and Technology, Nanchang University,Nanchang 330047,ChinaBeijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention,Beijing 100013,ChinaBeijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention,Beijing 100013,ChinaState Key Laboratory of Food Science and Technology, Nanchang University,Nanchang 330047,ChinaState Key Laboratory of Food Science and Technology, Nanchang University,Nanchang 330047,ChinaBeijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention,Beijing 100013,ChinaState Key Laboratory of Food Science and Technology, Nanchang University,Nanchang 330047,China;Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention,Beijing 100013,ChinaState Key Laboratory of Natural and Biomimetic Drugs, Peking University,Beijing 100191,ChinaBeijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention,Beijing 100013,ChinaBeijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention,Beijing 100013,ChinaState Key Laboratory of Natural and Biomimetic Drugs, Peking University,Beijing 100191,ChinaState Key Laboratory of Natural and Biomimetic Drugs, Peking University,Beijing 100191,ChinaBeijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention,Beijing 100013,ChinaState Key Laboratory of Natural and Biomimetic Drugs, Peking University,Beijing 100191,China;Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention,Beijing 100013,ChinaBeijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention,Beijing 100013,ChinaBeijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention,Beijing 100013,China

DOI  :  10.1039/C4AY03063J

学科分类：分析化学

来源: Royal Society of Chemistry

【 摘 要 】

6-Acetyl-1,1,2,4,4,7-hexamethyltetraline (AHTN) is widely used polycyclic musk with raised environmental and health concerns during the last decade, but the metabolites of AHTN in model animals such as rats are unknown. In this study, the major metabolites of AHTN in rat urine and feces were identified by ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UPLC/ESI-QTOF-MS). Three hydroxylation metabolites and three carboxyl metabolites were found in urine and feces.

【 授权许可】

Unknown