Unbound free fatty acid concentrations are increased in cardiac ischemia

Clinical Proteomics

Fred S. Apple³  Jesse Adams¹  Alan M. Kleinfeld² 

[1] University of Louisville and Jewish Hospital Heart and Lung Institute, Louisville,University of Louisville and Jewish Hospital Heart and Lung Institute, Louisville,University of Louisville and Jewish Hospital Heart and Lung Institute, Louisville,;Torrey Pines Institute for Molecular Studies and FFA Sciences LLC, San Diego, Torrey Pines Institute for Molecular Studies and FFA Sciences LLC, San Diego, Torrey Pines Institute for Molecular Studies and FFA Sciences LLC, San Diego,;Hennepin County Medical Center and University of Minnesota School of Medicine, Minneapolis, Hennepin County Medical Center and University of Minnesota School of Medicine, Minneapolis, Hennepin County Medical Center and University of Minnesota School of Medicine, Minneapolis,

关键词: Unbound free fatty acids;    ischemia;    myocardium;    cardiac troponin;   

DOI  :  10.1385/CP:1:1:041

来源: Humana Press Inc

【 摘 要 】

Abstract

Monitoring increased plasma unbound free fatty acid (FFA_u) concentrations has been proposed as a biomarker for myocardial ischemia. In the current study, 30 acute coronary syndrome (ACS) patients presenting in the emergency department, with chest pain within 12 h of onset, were clinically evaluated along with serial cardiac troponin I (cTnI) and FFA_u measurements.Increased FFA_u were found in 28 of 30 (93%) of ACS patients, ranging from 2.0 to 430 nM. For the nine ACS patients with myocardial infarction (MI), FFA_u levels were increased at presentation for all (100%). In contrast, cTnI was increased in only 9 of 30 (30%) patients, mean 0.7 μg/L, and in only 2 of 9 (22%) MI patients, mean 1.3 μg/L. During the 24 h following admission, cTnI increased in all 9 MI patients. FFA_u concentrations increased in every sample in which cTnI increased.Our findings suggest that FFA_u is increased in ischemia regardless of the presence or absence of myocardial necrosis, as reflected by increased or normal cTnI, respectively.

【 授权许可】

Unknown