期刊论文详细信息
Journal of the Korean Chemical Society | |
Diastereoselective Reduction of 2,3-Dioxo-4-carboxy-5-substituted Pyrrolidines Using NaBH4/AcOH and Heterogenous Hydrogenation Reactions | |
Mohd Fazli Mohammat1  Ahmad Sazali Hamzah1  Zurina Shaameri1  Nurul Shulehaf Mansor1  | |
关键词: 2; 3-Dioxo-pyrrolidine; Diastereoselective; Enol reduction; | |
DOI : | |
学科分类:化学(综合) | |
来源: Korean Chemical Society | |
【 摘 要 】
Diastereoselective reduction of 2,3-dioxo-4-carboxy-5-(substituted)pyrrolidine 1 by NaBH4/AcOH and heterogenous hydrogenation were reported. Stereochemical assignment and diastereomeric ratios of the products were determined using 1H NMR and single crystal X-ray analyses. The steric factors of the C-5 substituents of the pyrrolidinone was shown to have an interesting influence on both the yield and diastereoselectivity of the reduced product.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912010188327ZK.pdf | 372KB | download |