Measurement of Optical Purity for Commercially Avialable Dexibuprofen and Ibuprofen Sold in 2013

Journal of the Korean Chemical Society

Jeong Jae Yu¹  Hae Chan Seo¹  Jung Suk Song¹  Dong Hyun Ryoo¹  Hyun Young Kim¹  Jae Jeong Ryoo¹  Sang Heon Lee¹  Jae Hwan Lee¹  Sang Hyun Ryoo¹ 

关键词: Optical purity;    Commerical dexibuprofen;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The optical purity of 11 commercial dexibuprofens and 7 ibuprofens sold in Korea in 2013 were examined by chiral HPLC. The Chiralcel OD-H column and LUX-Cellulose-1 column were used as chiral stationary phases and the mixed eluent of hexane:isopropanol:acetic acid as 100:1:0.1 was used as a mobile phase with a flow rate of 1.0 mL/min. Each data was obtained from an average value of at least three different experiments for each sample and the average value of relative standard deviation of them appeared very small, 0.19%. Average optical purity value (97.5%) of eleven commercial dexibuprofens used in this study were smaller than those of 9 years ago (99.2%), but larger than four years ago (95.6%). Enantiomeric ratios of (R)- and (S)- isomers of seven ibuprofen samples used in this experiment were achieved at about 50:50 which was different with the result (44:56) from four years ago.

【 授权许可】

Unknown