Novel Synthesis of bis Acetylated Hybrid Pyrazoles as Potent Anticandidiasis Agents

Journal of the Korean Chemical Society

M Gopalakrishnan¹  V Kanagarajan¹  M R Ezhilarasi¹ 

关键词: Ç×Ä­´Ùµð¾Æ È°¼º;    Bis acetylated hybrid pyrazoles;    In situ acetylation;    Spectral analysis;    Candida sp.;    Anticandidal activity;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A new series of bis acetylated hybrid pyrazoles were synthesized and characterized by their melting point, elemental analysis, MS, FT-IR, one-dimensional 1H, and 13C NMR spectroscopic data. All the synthesized compounds were tested for their in vitro antifungal activities against Candida sp. namely Candida albicans, Candida glabrata, Candida parapsilosis, Candida dubliniensis and Candida tropicalis. A close inspection of the in vitro anticandidal activity profile in differently electron donating (CH3 and OCH3) and electron withdrawing (-F, -Cl, and Br) functional group substituted phenyl rings of novel hybrid pyrazoles exerted strong anticandidal activity against all the tested Candida species.

【 授权许可】

Unknown