Highly Convenient and Large Scale Synthesis of 5-chloroindole and its 3-substituted Analogues

Journal of the Korean Chemical Society

Sadanandam Palle¹  Laxminarayana Keetha¹  Mukkanti Khagga¹  Rajendiran Chinnapillai¹  Vinodkumar Ramanatham¹ 

关键词: 5-haloindoles;    copper (I) chloride;    N-methyl-2-pyrrolidone;    halogen-halogen exchange.;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A large scale and commercially feasible synthesis of 5-chloroindole and its 3-substituted analogues has been described via a halogen - halogen exchange reaction from 5-bromoindole and its derivatives using cuprous chloride and dipolar aprotic solvent N-methyl-2-pyrrolidone in one pot with good yields.

【 授权许可】

Unknown