DNA Binding Studies and Cytotoxicity of the Novel 1,10-phenanthroline Palladium(II) Complexes of Dithiocarbamate Derivatives

Journal of the Korean Chemical Society

Ali Akbar Saboury¹  Hassan Mansouri Torshizi¹  Zahra Yekke Ghasemi¹  Adeleh Divsalar¹  Mahmood Khastan¹  Maryam Saeidifar¹ 

关键词: DNA binding;    Pd(II) complex;    piperidinedithiocarbamate;    morpholinedithiocarbamate;    cytotoxicity;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Two new palladium (II) complexes, [Pd (phen)(pip-dtc)]NO3 and [Pd(phen)(mor-dtc)]NO3, (where phen is 1,10-Phenantroline, pip-dtc is piperidinedithiocarbamate anion and mor-dtc is morpholinedithiocarbamate anion) have been synthesized and characterized by elemental analysis, spectroscopic studies (FT-IR, 1 H NMR, UV-Vis) and conductance measurement. In these complexes, the dithiocarbamate ligands coordinate with Pd (II) center as bidentate with two sulfur atoms. These two complexes have been tested against chronic myelogenous leukemia cell line, K562. They show IC50 values less than cisplatin and thus the mode of binding of the complexes to calf thymus DNA (CT-DNA) were investigated by ultraviolet difference and fluorescence spectroscopy. They can denature DNA, exhibit cooperative binding and intercalate into DNA. Several binding and thermodynamic parameters are also described.

【 授权许可】

Unknown