Development and Validation of Simultaneous UV Spectrophotometric Method for the Determination of Levofloxacin and Ambroxol in Tablets

Journal of the Korean Chemical Society

Tabassum Patil¹  Yogesh Pore¹ 

关键词: Levofloxacin Hemihydrate;    Ambroxol Hydrochloride;    UV Spectrophometry;    Q analysis;    Dosage Form;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

An accurate, specific and precise UV spectrophotometric method was developed for the simultaneous determination of levofloxacin (LFX) and ambroxol (ABX) in pharmaceutical dosage forms. The method involves formation of Q-absorbance equation at 219 (isoabsorptive point) and at 287 nm, using distilled water as a solvent. The linearity for both levofloxacin and ambroxol was in the range of 2-20 ¥ìg/ml and 5-50 ¥ìg/ml respectively. The % recovery was found to be 100-101% and 99-102% for levofloxacin and ambroxol respectively indicating proposed method is accurate and precise for simultaneous estimation of levofloxacin and ambroxol in tablets.

【 授权许可】

Unknown