Synthesis and Antimicrobial Activity of Dimethyl (2-cyanophenylamino) (Substituted Aryl) Methyl Phosphonates

Journal of the Korean Chemical Society

C Suresh Reddy¹  G Chandra Sekhar Reddy¹  M Veera Narayana Reddy¹  A Uma Ravi Sankar¹  B Siva Kumar¹ 

关键词: Ç×±ÕÈ°¼ºµµ;    2-amino Benzonitrile;    Dimethylphosphite;    Kabachnic-Fields Reaction;    ¥á-aminophosphonic Acid Esters;    Antimicrobial Activity;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A new class of ¥á-aminophosphonic acid esters (4a-l) have been synthesized by three component one-pot reaction with equimolar quantities of 2-amino benzonitrile (1), dimethylphosphite (3) and various aldehydes (2a-l) in dry toluene at reflux conditions via Kabachnic-Fields reaction in high yields (74-85%).The structure of title compounds has been established by elemental, IR, 1H, 13C, 31P and Mass spectral analysis. They were found to possess significant antimicrobial activity.

【 授权许可】

Unknown