Unusual Formation of N-hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one and its Thiosemicarbazide Derivative-Synthesis and Antimicrobial Activity

Journal of the Korean Chemical Society

J. Thanusu,V. Kanagarajan¹  P. Sureshkumar¹  M. Gopalakrishnan¹ 

关键词: Ç×±Õ È°¼ºµµ;    N-Hydroxy-3;    3-dimethyl-2;    6-diarylpiperidin-4-one Thiosemicarbazones;    m-chloroperbenzoic Acid;    Stereochemistry;    Antimicrobial;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

An array of novel N-Hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one thiosemicarbazones 28-32 are synthesized, characterized by melting point, elemental analysis, MS, FT-IR, NMR (1H & 13C) spectroscopic data and evaluated for their in vitro antibacterial and antifungal activities. Of all the compounds synthesized, compound 31, exerted a wide range of antibacterial activities against the entire tested gram-positive and gram-negative bacterial strains except Escherichia coli. Compound 31 exerted strong antifungal activities against Aspergillus flavus, Mucor and Microsporum gypsuem.

【 授权许可】

Unknown