Association of BIM Deletion Polymorphism and BIM-γ RNA Expression in NSCLC with EGFR Mutation

Cancer Genomics - Proteomics

TETSUO MIKAMI²  KYOHEI KABURAKI³  HAJIME OTSUKA⁴  YUJIRO TAKAI³  AKIRA IYODA²  SAKAE HOMMA³  TAKASHI MAKINO⁴  NAOBUMI TOCHIGI¹  GO SANO³  SUSUMU SAKAMOTO³  KEISHI SUGINO³  KAZUTOSHI ISOBE³  HIROSHI KOBAYASHI³  ATSUSHI KAKIMOTO³  TAKAHIRO YOSHIZAWA³ 

[1] ivision of Surgical Pathology, Toho University School of Medicine, Tokyo, Japanivision of Surgical Pathology, Toho University School of Medicine, Tokyo, Japanivision of Surgical Pathology, Toho University School of Medicine, Tokyo, Japan;ivision of Pathology, Toho University School of Medicine, Tokyo, Japanivision of Pathology, Toho University School of Medicine, Tokyo, Japanivision of Pathology, Toho University School of Medicine, Tokyo, Japan;ivision of Respiratory Medicine, Toho University School of Medicine, Tokyo, Japanivision of Respiratory Medicine, Toho University School of Medicine, Tokyo, Japanivision of Respiratory Medicine, Toho University School of Medicine, Tokyo, Japan;ivision of Chest Surgery, Toho University School of Medicine, Tokyo, Japanivision of Chest Surgery, Toho University School of Medicine, Tokyo, Japanivision of Chest Surgery, Toho University School of Medicine, Tokyo, Japan

关键词: BIM;    non-small cell lung cancer;    epidermal growth factor receptor tyrosine kinase inhibitor;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Aim: This pilot study assessed the association of BIM deletion polymorphism and BIM RNA isoform in patients with EGFR-positive non-small cell lung cancer (NSCLC). Patients and Methods: The study included 33 patients with EGFR-positive NSCLC treated with gefitinib. BIM deletion polymorphism and BIM RNA isoform (EL/L/S/γ) were determined by polymerase chain reaction (PCR). Results: BIM-γ expression was significantly higher in patients with BIM deletion polymorphism than among those without BIM deletion polymorphism inside tumors (p=0.038) and around tumors (p=0.0024). Relative BIM-γ expression was significantly higher in patients with BIM deletion polymorphism than among those without BIM deletion polymorphism (p=0.0017). Patients with BIM-γ had significantly shorter progression-free survival than those without BIM-γ (median: 304 vs. 732 days; p=0.023). Conclusion: Expression of BIM-γ mRNA and BIM deletion polymorphism were strongly associated. BIM-γ overexpression may have a role in apoptosis related to EGFR-tyrosine kinase inhibitor.

【 授权许可】

Unknown