期刊论文详细信息
Cancer Genomics - Proteomics
Expression of microRNAs of C19MC in Different Histological Types of Testicular Germ Cell Tumour
INGA FLOR4  GAZANFER BELGE4  JÖRN BULLERDIEK3  KLAUS-PETER DIECKMANN1  MEIKE SPIEKERMANN4  THOMAS LÖNING2 
[1] epartment of Urology, Albertinen-Hospital, Hamburg, Germanyepartment of Urology, Albertinen-Hospital, Hamburg, Germanyepartment of Urology, Albertinen-Hospital, Hamburg, Germany;epartment of Pathology, Albertinen-Hospital, Hamburg, Germanyepartment of Pathology, Albertinen-Hospital, Hamburg, Germanyepartment of Pathology, Albertinen-Hospital, Hamburg, Germany;entre for Human Genetics, University of Bremen, Bremen, Germanynstitute of Medical Genetics, University Rostock Medical Centre, Rostock, Germanyentre for Human Genetics, University of Bremen, Bremen, Germanyentre for Human Genetics, University of Bremen, Bremen, Germanynstitute of Medical Genetics, University Rostock Medical Centre, Rostock, Germanynstitute of Medical Genetics, University Rostock Medical Centre, Rostock, Germanyentre for Human Genetics, University of Bremen, Bremen, Germanynstitute of Medical Genetics, University Rostock Medical Centre, Rostock, Germany;entre for Human Genetics, University of Bremen, Bremen, Germanyentre for Human Genetics, University of Bremen, Bremen, Germanyentre for Human Genetics, University of Bremen, Bremen, Germany
关键词: C19MC;    miRNA;    TGCT;    biomarker;    serum;   
DOI  :  
来源: Delinasios GJ CO
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【 摘 要 】

Background: Testicular germ cell tumours (TGCTs) are the most common tumours in men aged from 20 to 40 years, with a steadily increasing incidence. This study aimed to characterize the expression of the miRNA cluster C19MC in TGCT and to evaluate the suitability of a C19MC miRNA as a serum biomarker. Materials and Methods: By quantitative reverse transcription PCR, we measured the expression of miR-517a-3p, miR-519a-3p, and miR-519c 3p in tissue samples of 25 TGCTs and the level of miR-517a-3p in serum samples obtained pre- and postoperatively from the same patients. Results: We detected a significantly higher expression of C19MC miRNAs in non-seminomas than in seminomas and in clinical stages 2 and 3 than in stage 1 in both tissue and serum samples. Conclusion: miRNAs of C19MC are overexpressed in more aggressive types of TGCT, suggesting they contribute to malignancy. Furthermore, they might serve as serum biomarkers for these types of TGCT.

【 授权许可】

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