The Significance of Proteomic Biomarkers in Male Breast Cancer

Cancer Genomics - Proteomics

GEORGIOS TSANGARIS¹  MARIA GAZOULI²  EVANGELOS MARINOS²  ELENI ZOGRAFOS² 

[1] roteomics Research Unit, Center of Basic Research II, Biomedical Research Foundation of the Academy of Athens, Athens, Greeceroteomics Research Unit, Center of Basic Research II, Biomedical Research Foundation of the Academy of Athens, Athens, Greeceroteomics Research Unit, Center of Basic Research II, Biomedical Research Foundation of the Academy of Athens, Athens, Greece;epartment of Basic Medical Sciences, Laboratory of Biology, School of Medicine, University of Athens, Athens, Greeceepartment of Basic Medical Sciences, Laboratory of Biology, School of Medicine, University of Athens, Athens, Greeceepartment of Basic Medical Sciences, Laboratory of Biology, School of Medicine, University of Athens, Athens, Greece

关键词: Male breast cancer;    proteomics;    genetics;    biomarkers;    review;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Breast cancer in men (MBC) is an uncommon malignancy and accounts for only 1% of all diagnosed breast cancers. By using genomic and transcriptomic approaches, researchers have been able to expand our insight into the genetic basis of breast cancer, by providing new biomarkers. We currently know that gene analysis by itself does not show the complete picture. Along with the genomic approach, proteomics are crucial for the improvement of breast cancer diagnosis, sub-classification, for predicting response to different treatment modalities and for predicting prognosis. There are great challenges in identifying discriminatory proteins and the use of specific techniques along with additional analytical tools is required. A number of techniques allow testing for proteins produced during specific diseases. In this review, an effort is made to summarize the studies and results linked to the implementation of proteomics in the field of MBC detection and diagnosis.

【 授权许可】

Unknown