Identification of Prognostically Relevant Chromosomal Abnormalities in Routine Diagnostics of Multiple Myeloma Using Genomic Profiling

Cancer Genomics - Proteomics

EIGIL KJELDSEN⇑¹ 

[1]Haemodiagnostic Laboratory, Cancer Cytogenetics Section, Department of Haematology, Aarhus University Hospital, Aarhus, DenmarkHaemodiagnostic Laboratory, Cancer Cytogenetics Section, Department of Haematology, Aarhus University Hospital, Aarhus, DenmarkHaemodiagnostic Laboratory, Cancer Cytogenetics Section, Department of Haematology, Aarhus University Hospital, Aarhus, Denmark

关键词: Multiple myeloma;    cytogenetics;    aCGH;    prognostication;    ISS staging;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Background: The combination of serum β2-microglubulin and albumin levels is highly prognostic in multiple myeloma (MM), defined as the International Staging System (ISS). Recurrent genomic abnormalities present in myeloma cells also have a strong prognostic power. This study aimed to assess, in a routine diagnostic setting, whether genomic aberrations can be used to identify sub-groups in ISS staging, as this system does not incorporate intrinsic myeloma cell variability at the molecular level. Materials and Methods: A prospective population-based study of 123 patients newly diagnosed with MM with ISS staging were included for karyotyping, interphase nuclei fluorescence in situ hybridization (iFISH) and oligo-based array comparative genomic hybridization (oaCGH) analyses. Results: Clonal abnormalities were identified in 27% of analyses by karyotyping, in 83% by iFISH, and in 99% by oaCGH analysis. ISS staging combined with oaCGH aberrations identified ISS sub-groups. Conclusion: oaCGH analysis is a valuable asset in detecting prognostically relevant genomic abnormalities. The combination of oaCGH data with ISS staging might help define new sub-groups in MM.

【 授权许可】

Unknown