Molecular Mechanisms of Bone Metastasis

Cancer Genomics - Proteomics

FABIAN BIRZELE¹  GWENDLYN KOLLMORGEN¹  ULRICH H. WEIDLE¹  RÜDIGER RÜGER⇑¹ 

[1] Roche Pharma Research and Early Development, Roche Innovation Center Penzberg, Roche Diagnostics GmbH, Penzberg, GermanyRoche Pharma Research and Early Development, Roche Innovation Center Penzberg, Roche Diagnostics GmbH, Penzberg, GermanyRoche Pharma Research and Early Development, Roche Innovation Center Penzberg, Roche Diagnostics GmbH, Penzberg, Germany

关键词: Bisphosphonates;    bone tropism of metastasis;    denosumab;    genes mediating and modulating bone metastasis;    pre- and metastatic niche(s);    vicious cycle;    review;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Metastasis of breast and prostate cancer as well as multiple myeloma to the bones represents a significant medical problem. We herein discuss the molecular basis of the creation of pre-metastatic niches, the process of bone metastasis and the phenomenon of tumor dormancy in the bone marrow as well as its regulation. We describe the identification and validation of genes mediating bone metastasis by use of pre-clinical models of bone metastasis. Additionally, we discuss the role of small integrin binding N-linked glycoproteins (SIBLINGS), the chemokine/chemokine receptor CXCL12/CXCR4 pathway and the role of micro RNAs (miRNAs) as mediators of bone metastasis. Finally, we summarize clinical achievements for the treatment of bone metastases.

【 授权许可】

Unknown