Impact of PTEN IVS4 Polymorphism (rs3830675) on Cancer Susceptibility: An Updated Meta-analysis

Cancer Genomics - Proteomics

HELEN YANG³  JI LUO²  JINNIAN GE²  YUE WANG¹ 

[1] epartment of Surgery, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, P.R. Chinaepartment of Surgery, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, P.R. Chinaepartment of Surgery, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, P.R. China;epartment of General Surgery, the First Hospital of China Medical University, Shenyang, Liaoning, P.R. Chinaepartment of General Surgery, the First Hospital of China Medical University, Shenyang, Liaoning, P.R. Chinaepartment of General Surgery, the First Hospital of China Medical University, Shenyang, Liaoning, P.R. China;nstitute of Public Health, University of California, San Francisco, CA, U.S.A.nstitute of Public Health, University of California, San Francisco, CA, U.S.A.nstitute of Public Health, University of California, San Francisco, CA, U.S.A.

关键词: PTEN;    polymorphism;    cancer;    meta-analysis;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Background/Aim: Phosphatase and tensin homolog (PTEN) acts as a tumor suppressor gene through the action of its phosphatase protein product. We performed a meta-analysis to evaluate their relationship. Materials and Methods: A comprehensive database search was performed. Odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the association between PTEN IVS4 polymorphism and cancer. Results: The meta-analysis indicated that PTEN IVS4 (−/−) genotype was significantly associated with the risk of cancer (OR=1.47, 95% CI=1.11-1.84), especially for digestive cancer (OR=1.67, 95% CI=1.28-2.18) compared to the (+/+) genotype. Moreover, the (−) allele of PTEN IVS4 polymorphism was also significantly associated with the risk of cancer (OR=1.27, 95% CI=1.14-1.41), especially for digestive cancer (OR=1.42, 95% CI=1.16-1.74) compared to the (+) allele. No significant association was observed between PTEN IVS4 (+/−) genotype and risk of cancer. Conclusion: PTEN IVS4 (−/−) genotype was significantly associated with increased risk of cancer especially for digestive tract cancer compared to the (+/+) genotype. A similar phenomenon was observed in the (−) allele of PTEN IVS4 polymorphism compared to the (+) allele and the recessive effect model.

【 授权许可】

Unknown