MicroRNA-150 Is up-regulated in Extranodal Marginal Zone Lymphoma of MALT Type

Cancer Genomics - Proteomics

ARNE SCHILLERT²  NIKLAS GEBAUER¹  JOHANNES KUBA¹  ANDREA SENFT²  CHRISTOPH THORNS¹  VERONICA BERNARD¹ 

[1] Department of Pathology, Reference Center for Lymph Node Pathology and Hematopathology, University Hospital of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany Department of Pathology, Reference Center for Lymph Node Pathology and Hematopathology, University Hospital of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany Department of Pathology, Reference Center for Lymph Node Pathology and Hematopathology, University Hospital of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany;Department of medical Biometrics and Statistics, University of Lübeck, Luebeck, Germany Department of medical Biometrics and Statistics, University of Lübeck, Luebeck, Germany Department of medical Biometrics and Statistics, University of Lübeck, Luebeck, Germany

关键词: MicroRNA;    gastritis;    MALT;    lymphoma;    malignant transformation;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Background: The mechanisms promoting malignant transformation from chronic Helicobacter pylori-gastritis to gastric extranodal marginal zone lymphoma (MALT lymphoma) are insufficiently characterized. This follow-up study aimed to validate candidate microRNAs (miRs) in the process of neoplastic transformation. Materials and Methods: MicroRNA expression signatures (n=20) were generated for a total of 60 cases of gastric lesions ranging from Wotherspoon 0-5 employing a quantitative real-time polymerase chain reaction (PCR) approach. Morphological and immunohistochemical characterization of the cohort was supplemented by PCR-based immunoglobulin heavy chain recombination studies. Results: Quantitative expression of miR-150, miR-142.3p, miR-375 and miR-494 was significantly de-regulated in samples from MALT lymphoma compared to those from gastritis. Conclusion: The previously reported up-regulation of miR-150 in marginal zone lymphoma of MALT type was verified in an independent cohort of lymphoma samples employing a modified methodology. This further substantiates the role of miR-150 as a potential oncomiR in MALT lymphoma.

【 授权许可】

Unknown