Serum and Tissue Metabolomics of Head and Neck Cancer

Cancer Genomics - Proteomics

JUNKO KITAMOTO-MATSUDA¹  NAOKI OTSUKI¹  KEN-ICHI NIBU¹  MASAKAZU SHINOHARA⁴  TAKESHI FUJITA¹  KOICHI MORIMOTO¹  MASARU YOSHIDA³  MIKI SAITO¹  KOICHIRO YONEZAWA¹  DAISUKE YAMASHITA¹  SHIN NISHIUMII²  YASUHIRO IRINO⁴ 

[1] Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kobe University, Kobe, JapaDepartment of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kobe University, Kobe, JapaDepartment of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kobe University, Kobe, Japa;Division of Gastroenterology, Graduate School of Medicine, Kobe University, Kobe, JapaDivision of Gastroenterology, Graduate School of Medicine, Kobe University, Kobe, JapaDivision of Gastroenterology, Graduate School of Medicine, Kobe University, Kobe, Japa;Division of Gastroenterology, Graduate School of Medicine, Kobe University, Kobe, JapaThe Integrated Center for Mass Spectrometry, Graduate School of Medicine, Kobe University, Kobe, JapaDivision of Metabolomics Research, Graduate School of Medicine, Kobe University, Kobe, JapaDivision of Gastroenterology, Graduate School of Medicine, Kobe University, Kobe, JapaDivision of Gastroenterology, Graduate School of Medicine, Kobe University, Kobe, JapaThe Integrated Center for Mass Spectrometry, Graduate School of Medicine, Kobe University, Kobe, JapaDivision of Metabolomics Research, Graduate School of Medicine, Kobe University, Kobe, JapaThe Integrated Center for Mass Spectrometry, Graduate School of Medicine, Kobe University, Kobe, JapaDivision of Gastroenterology, Graduate School of Medicine, Kobe University, Kobe, JapaThe Integrated Center for Mass Spectrometry, Graduate School of Medicine, Kobe University, Kobe, JapaDivision of Metabolomics Research, Graduate School of Medicine, Kobe University, Kobe, JapaDivision of Metabolomics Research, Graduate School of Medicine, Kobe University, Kobe, JapaDivision of Gastroenterology, Graduate School of Medicine, Kobe University, Kobe, JapaThe Integrated Center for Mass Spectrometry, Graduate School of Medicine, Kobe University, Kobe, JapaDivision of Metabolomics Research, Graduate School of Medicine, Kobe University, Kobe, Japa;The Integrated Center for Mass Spectrometry, Graduate School of Medicine, Kobe University, Kobe, JapaThe Integrated Center for Mass Spectrometry, Graduate School of Medicine, Kobe University, Kobe, JapaThe Integrated Center for Mass Spectrometry, Graduate School of Medicine, Kobe University, Kobe, Japa

关键词: Metabolomics;    serum;    tissue;    glycolytic pathway;    amino acid;    head and neck cancer;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Background: No reliable clinical markers to diagnose early stage-disease and predict its prognosis have yet been found for squamous cell carcinoma of the head and neck (HNSCC). Materials and Methods: In the present study, the metabolomic analysis of serum and tissue samples obtained from patients with HNSCC was performed using gas chromatography/mass spectrometry. Results: In serum, levels of several metabolites related to the glycolytic pathway, such as glucose, were higher in patients with HNSCC, and the levels of several amino acids were lower. In contrast to sera, the levels of many metabolites related to the glycolytic pathway appeared to be lower in tumor tissues of HNSCC than in non-tumorous tissues, and the levels of several amino acids, such as valine, thyrosine, serine and methionine, were higher. Conclusion: Our results demonstrate that changes in metabolite patterns are useful in assessing the clinical characteristics of HNSCC, and will hopefully lead to the establishment of novel diagnostic tools.

【 授权许可】

Unknown