TGF-β1 Interactome: Metastasis and Beyond

Cancer Genomics - Proteomics

R.J. DISTEL¹  C.S. TSANG²  L.P. SAMARANAYAKE²  W.P. KUO¹  A.J. TRACHTENBERG¹  G.B. SMEJKAL¹  L. OHNO-MACHADO³  J.N. LACY¹  M.G. SMITH³  V. RICCHIUTI¹  M. PERERA² 

[1] Harvard Medical School, Boston, MA, U.S.A.Harvard Medical School, Boston, MA, U.S.A.Harvard Medical School, Boston, MA, U.S.A.;University of Hong Kong, Hong KongUniversity of Hong Kong, Hong KongUniversity of Hong Kong, Hong Kong;Florida Hospital Ormond Memoerial, Ormond Beach, FL, U.S.A.Florida Hospital Ormond Memoerial, Ormond Beach, FL, U.S.A.Florida Hospital Ormond Memoerial, Ormond Beach, FL, U.S.A.

关键词: Transforming growth factor-β1;    diagnostics;    interactome;    metastatsis;    therapeutics;    review;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

The ubiquitous cytokine transforming growth factor-β1 (TGF-β1) is one of the most potent metastatic inducers. Functional interactomic mapping using high-throughput proteomic and genomic data provides valuable insights into the regulation of tumor suppressive and metastatic attributes of TGF-β1. Polarity changes of the TGF-β1 interactome at a given time contributes to these contrasting effects. Differential expression profiles of pivotal interactomic nodes contribute to these polarity changes. These insights are of immense value in the development of effective cancer therapeutics. Moreover, TGF-β1 interactomic nodes are useful in discovering novel cancer biomarkers. This review describes an initial version of the TGF-β1 interactome in relation to tumor progression and metastasis. Thus, this review embodies an important step towards the mapping of comprehensive and individualized TGF-β1 interactomes that will assist in the development of personalized cancer therapeutics.

【 授权许可】

Unknown