Cancer Stem Cells and Individualized Therapy

Cancer Genomics - Proteomics

PORNIMA PHATAK¹  SARANYA CHUMSRI³  ANNE W. HAMBURGER²  ANGELIKA M. BURGER¹  MARTIN J. EDELMAN³  NAZANIN KHAKPOUR⁴ 

[1] epartment of Pharmacology and Experimental Therapeutics, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, U.S.A.epartment of Pharmacology and Experimental Therapeutics, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, U.S.A.epartment of Pharmacology and Experimental Therapeutics, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, U.S.A.;epartment of Pathology, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, U.S.A.epartment of Pathology, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, U.S.A.epartment of Pathology, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, U.S.A.;epartment of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, U.S.A.epartment of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, U.S.A.epartment of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, U.S.A.;epartment of Surgery, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, U.S.A.epartment of Surgery, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, U.S.A.epartment of Surgery, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, U.S.A.

关键词: Human tumor stem cell assay (HTCA);    side population;    clonogenicity;    cancer stem cells;    review;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

The concept of individualized cancer chemotherapy emerged three decades ago from the observation that a small fraction of cells in primary tumors can form colonies in soft agar similar to stem cells of the hematopoietic system. In a series of retrospective and prospective clinical studies, clonogenic tumor growth and effects of anticancer agents on the putative cancer stem cells were assessed as predictive factors. The results of these trials showed that clonogenic growth is associated with poor outcome and drug resistance. Recent breakthroughs enabling isolation and the molecular classification of cancer stem cells have renewed interest in cancer stem cells as a therapeutic target. Here, we provide a current overview of cancer stem cell biology and highlight possibilities for targeted intervention with existing and novel experimental anticancer agents.

【 授权许可】

Unknown