The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes

Journal of Leukocyte Biology

Janine Doorduin–²  Hemmo A. Drexhage¹  Roosmarijn C. Drexhage¹  Lorena Pont-Lezica⁵  Hans C. Klein–²  Johann Steiner⁷  Thomas J. Connor³  Sinead M. Gibney ⁴  Marjan A. Versnel and¹  Wouter Beumer¹  Andrew Harkin⁶ 

[1] Department of Immunology, Erasmus MC, Rotterdam, the Netherlands;–Department of Psychiatry and Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Physiology and School of Medicine and Department of Immunology, Erasmus MC, Rotterdam, the Netherlands; Department of Physiology and School of Medicine and School of Pharmacy and Pharmaceutical Sciences, Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland;Institut de Biologie de l'Ecole Normale Supérieure, INSERM, Paris, France;School of Pharmacy and Pharmaceutical Sciences, Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland;Department of Psychiatry, University of Magdeburg, Magdeburg, Germany Department of Immunology, Erasmus MC, Rotterdam, the Netherlands;

关键词: schizophrenia;    bipolar disorder;    animal models;    PET;    NOD mouse;   

DOI  :  10.1189/jlb.0212100

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

This review describes a key role for mononuclear phagocytes in the pathogenesis of major psychiatric disorders. There is accumulating evidence for activation of microglia (histopathology and PET scans) and circulating monocytes (enhanced gene expression of immune genes, an overproduction of monocyte/macrophage-related cytokines) in patients with bipolar disorder, major depressive disorder, and schizophrenia. These data are strengthened by observations in animal models, such as the MIA models, the chronic stress models, and the NOD mouse model. In these animal models of depressive-, anxiety-, and schizophrenia-like behavior, similar activations of microglia and circulating monocytes can be found. These animal models also make in-depth pathogenic studies possible and show that microglia activation impacts neuronal development and function in brain areas congruent with the altered depressive and schizophrenia-like behaviors.

【 授权许可】

Unknown