Systemic inflammation and fracture healing

Journal of Leukocyte Biology

Leo Koenderman  and¹  Janesh Pillay¹  Luke Leenen¹  Taco Blokhuis¹  Okan Bastian¹  Jacqueline Alblas¹ 

[1] Departments of Surgery,  Pulmonary Diseases, and Orthopedics, University Medical Center Utrecht, The Netherlands

关键词: leukocytosis;    neutrophil;    priming;    bone;    repair;   

DOI  :  10.1189/jlb.0810446

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Apart from their pivotal role in the host defense against pathogens, leukocytes are also essential for bone repair, as fracture healing is initiated and directed by a physiological inflammatory response. Leukocytes infiltrate the fracture hematoma and produce several growth and differentiation factors that regulate essential downstream processes of fracture healing. Systemic inflammation alters the numbers and properties of circulating leukocytes, and we hypothesize that these changes are maintained in tissue leukocytes and will lead to impairment of fracture healing after major trauma. The underlying mechanisms will be discussed in this review.

【 授权许可】

Unknown