Macrophages: do they impact AIDS progression more than CD4 T cells?

Journal of Leukocyte Biology

Marcelo J. Kuroda¹ 

[1] Division of Immunology, Tulane National Primate Research Center, Tulane University Health Science Center, Covington, Louisiana, USA Division of Immunology, Tulane National Primate Research Center, Tulane University Health Science Center, Covington, Louisiana, USA Division of Immunology, Tulane National Primate Research Center, Tulane University Health Science Center, Covington, Louisiana, USA

关键词: innate cell-mediated immunity;    apoptosis;    phagocytosis;    HIV;   

DOI  :  10.1189/jlb.0909626

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Destruction of CD4+ T cells is considered to be the main cause of immunodeficiency manifested by opportunistic infections in HIV-1-infected humans, as well as in SIV-infected macaques. We propose that monocyte/macrophage lineage cells also play an important role in the pathogenesis of AIDS, based on our recent work with the SIV/rhesus macaque animal model. We propose that damage to CD4+ T cells is important and readily apparent, but damage to monocyte/macrophage lineage cells, although less obvious, may provide the missing link to predict the onset of opportunistic infections and progression to AIDS.

【 授权许可】

Unknown