HIV interactions with dendritic cells: has our focus been too narrow?

Journal of Leukocyte Biology

Anthony L. Cunningham¹  Heather Donaghy¹  John Wilkinson¹ 

[1] Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Sydney, New South Wales, AustraliaCentre for Virus Research, Westmead Millennium Institute and University of Sydney, Sydney, New South Wales, AustraliaCentre for Virus Research, Westmead Millennium Institute and University of Sydney, Sydney, New South Wales, Australia

关键词: pathogenesis;    immune responses;   

DOI  :  10.1189/jlb.0306158

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Although few in number, dendritic cells (DCs) are heterogeneous, ubiquitous, and are crucial for protection against pathogens. In this review, the different DC subpopulations have been described and aspects of DC biology are discussed. DCs are important, not only in the pathogenesis of HIV, but also in the generation of anti-HIV immune responses. This review describes the roles that DC are thought to play in HIV pathogenesis, including uptake and transport of virus. We have also discussed the effects that the virus exerts on DCs such as infection and dysfunction. Then we proceed to focus on DC subsets in different organs and show how widespread the effects of HIV are on DC populations. It is clear that the small number of studies on tissue-derived DCs limits current research into the pathogenesis of HIV.

【 授权许可】

Unknown