Journal of Leukocyte Biology | |
Comparative inflammatory properties of staphylococcal superantigenic enterotoxins SEA and SEG: implications for septic shock | |
Cédric Badiou3  Gerard Lina3  Damien Thomas3  Olivier Dauwalder3  Tristan Ferry3  Anne-Lise Debard1  Guillaume Monneret2  François Vandenesch3  Jerome Etienne3  | |
[1] Hospices Civils de Lyon, CH Lyon-Sud, and Hospices Civils de Lyon, CH Lyon-Sud, and Hospices Civils de Lyon, CH Lyon-Sud, and;Université Claude Bernard, INSERM E230, IFR-62, Faculté de Médecine Laennec, Lyon, France; and Hôpital Neurologique, Laboratoire d’Immunologie, Lyon, France Université Claude Bernard, INSERM E230, IFR-62, Faculté de Médecine Laennec, Lyon, France; and Université Claude Bernard, INSERM E230, IFR-62, Faculté de Médecine Laennec, Lyon, France; and Hôpital Neurologique, Laboratoire d’Immunologie, Lyon, France Hôpital Neurologique, Laboratoire d’Immunologie, Lyon, France Université Claude Bernard, INSERM E230, IFR-62, Faculté de Médecine Laennec, Lyon, France; and Hôpital Neurologique, Laboratoire d’Immunologie, Lyon, France;Université Claude Bernard, INSERM E230, IFR-62, Faculté de Médecine Laennec, Lyon, France; and Université Claude Bernard, INSERM E230, IFR-62, Faculté de Médecine Laennec, Lyon, France; and Université Claude Bernard, INSERM E230, IFR-62, Faculté de Médecine Laennec, Lyon, France; and | |
关键词: superantigens; bacterial; cytokines; chemokines; Staphylococcus aureus; | |
DOI : 10.1189/jlb.0306232 | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
The severity of Staphylococcus aureus sepsis is positively associated with staphylococcal enterotoxin A (SEA) and negatively associated with the enterotoxin gene cluster (egc), which encodes five staphylococcal enterotoxins [1]. We postulated that the variable, clinical severity of S. aureus sepsis might be a result of differences in the inflammatory properties of staphylococcal superantigens. We therefore compared the inflammatory properties of SEA with those of staphylococcal entérotoxin G (SEG), a member of the five egc superantigens. We found that SEA and SEG had similar superantigenic properties, as they induced CD69 expression on T lymphocytes and selective expansion of Vβ subpopulations. Contrary to SEG, however, SEA induced a strong proinflammatory/Th1 response, including TNF-α and MIP-1α production. These results suggest that the association of SEA with the severity of S. aureus septic shock, characterized by a deleterious, inflammatory cascade, may be explained partly by the specific proinflammatory properties of this superantigen.
【 授权许可】
Unknown
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