Comparative inflammatory properties of staphylococcal superantigenic enterotoxins SEA and SEG: implications for septic shock

Journal of Leukocyte Biology

Cédric Badiou³  Gerard Lina³  Damien Thomas³  Olivier Dauwalder³  Tristan Ferry³  Anne-Lise Debard¹  Guillaume Monneret²  François Vandenesch³  Jerome Etienne³ 

[1] Hospices Civils de Lyon, CH Lyon-Sud, and Hospices Civils de Lyon, CH Lyon-Sud, and Hospices Civils de Lyon, CH Lyon-Sud, and;Université Claude Bernard, INSERM E230, IFR-62, Faculté de Médecine Laennec, Lyon, France; and Hôpital Neurologique, Laboratoire d’Immunologie, Lyon, France Université Claude Bernard, INSERM E230, IFR-62, Faculté de Médecine Laennec, Lyon, France; and Université Claude Bernard, INSERM E230, IFR-62, Faculté de Médecine Laennec, Lyon, France; and Hôpital Neurologique, Laboratoire d’Immunologie, Lyon, France Hôpital Neurologique, Laboratoire d’Immunologie, Lyon, France Université Claude Bernard, INSERM E230, IFR-62, Faculté de Médecine Laennec, Lyon, France; and Hôpital Neurologique, Laboratoire d’Immunologie, Lyon, France;Université Claude Bernard, INSERM E230, IFR-62, Faculté de Médecine Laennec, Lyon, France; and Université Claude Bernard, INSERM E230, IFR-62, Faculté de Médecine Laennec, Lyon, France; and Université Claude Bernard, INSERM E230, IFR-62, Faculté de Médecine Laennec, Lyon, France; and

关键词: superantigens;    bacterial;    cytokines;    chemokines;    Staphylococcus aureus;   

DOI  :  10.1189/jlb.0306232

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

The severity of Staphylococcus aureus sepsis is positively associated with staphylococcal enterotoxin A (SEA) and negatively associated with the enterotoxin gene cluster (egc), which encodes five staphylococcal enterotoxins [1]. We postulated that the variable, clinical severity of S. aureus sepsis might be a result of differences in the inflammatory properties of staphylococcal superantigens. We therefore compared the inflammatory properties of SEA with those of staphylococcal entérotoxin G (SEG), a member of the five egc superantigens. We found that SEA and SEG had similar superantigenic properties, as they induced CD69 expression on T lymphocytes and selective expansion of Vβ subpopulations. Contrary to SEG, however, SEA induced a strong proinflammatory/Th1 response, including TNF-α and MIP-1α production. These results suggest that the association of SEA with the severity of S. aureus septic shock, characterized by a deleterious, inflammatory cascade, may be explained partly by the specific proinflammatory properties of this superantigen.

【 授权许可】

Unknown